Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk

Jasmine A McDonald; Yuyan Liao; Julia A Knight; Esther M John; Allison W Kurian; Mary Daly; Saundra S Buys; Yun Huang; Caren J Frost; Irene L Andrulis; Sarah V Colonna; Michael L Friedlander; John L Hopper; Wendy K Chung; Jeanine M Genkinger; Robert J MacInnis; Mary Beth Terry; Kathleen Cuningham Foundation Consortium investigators

Journal article

Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk

Jasmine A McDonald, Yuyan Liao, Julia A Knight, Esther M John, Allison W Kurian, Mary Daly, Saundra S Buys, Yun Huang, Caren J Frost, Irene L Andrulis, Sarah V Colonna, Michael L Friedlander, John L Hopper, Wendy K Chung, Jeanine M Genkinger, Robert J MacInnis, Mary Beth Terry, undefined Kathleen Cuningham Foundation Consortium investigators

JAMA network open | JAMA Network | Published : 2024

DOI: 10.1001/jamanetworkopen.2024.27441

Abstract

IMPORTANCE: Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in BC risk is critical to understanding BC causes and for developing effective risk-based screening guidelines. OBJECTIVE: To examine the association between pregnancy-related factors and BC risk, including modification by a of BC where scores are based on age and BC family history. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included participants from the prospective Family Study Cohort (ProF-SC), which includes the 6 sites of the Breast Cancer Family Registry (US, Canada, and Australia)..

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University of Melbourne Researchers

Robert MacInnis Author

Mark Jenkins Author

Sue-Anne McLachlan Author

Roger Milne Author

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Grants

Awarded by Cancer Council Queensland

Funding Acknowledgements

The 6 sites of the Breast Cancer Family Registry were supported by grant No. U01 CA164920 from the US National Cancer Institute. This work was also supported by grants to the Kathleen Cuningham Foundation Consortium for research into Familial Breast Cancer (KCF) and the KCF Follow-Up Study from Cancer Australia (grant Nos. 809195 and 1100868); the Australian National Breast Cancer Foundation (grant No. IF 17kConFab); the National Health and Medical Research Council (grant No. 454508, 288704, and 145684); the USNIH (grant No. R01CA159868); the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia; and the Cancer Foundation of Western Australia. Dr McDonald is also supported by the US National Cancer Institute (grant No. R01CA267897)